Methanol → N-(cyclopropylmethyl)-3-[8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylbenzamide

HRID 102696

Reaction equation

HRID 102696 reaction equation
[BH4-:36].[CH3:38][OH:39].[CH:1]1([CH2:4][NH:5][C:6]([c:7]2[cH:8][c:9](-[c:14]3[c:15]4[c:16]([n:17][c:18]([S:20][CH3:21])[n:19]3)[n:22](-[c:27]3[c:28]([F:34])[cH:29][cH:30][cH:31][c:32]3[F:33])[c:23](=[O:26])[cH:24][cH:25]4)[c:10]([CH3:13])[cH:11][cH:12]2)=[O:35])[CH2:2][CH2:3]1.[Na+:37].[Ni:46]([Cl:47])[Cl:48].[OH2:40].[OH2:41].[OH2:42].[OH2:43].[OH2:44].[OH2:45]>>[CH:1]1([CH2:4][NH:5][C:6]([c:7]2[cH:8][c:9](-[c:14]3[c:15]4[c:16]([n:17][cH:18][n:19]3)[n:22](-[c:27]3[c:28]([F:34])[cH:29][cH:30][cH:31][c:32]3[F:33])[c:23](=[O:26])[cH:24][cH:25]4)[c:10]([CH3:13])[cH:11][cH:12]2)=[O:35])[CH2:2][CH2:3]1

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ionHCID 962Water6×HCID 24385Nickel DichlorideHCID 28123BorohydrideHCID 57434552N-(cyclopropylmethyl)-3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylbenzamide

Product 1

HCID 11948233N-(cyclopropylmethyl)-3-[8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylbenzamide

Sources & evidence

ORD record
ord-71f4a46c42814c789e83c55b6645344c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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