2,2-Difluoro-1,3-dioxaindan-4-amine → HCID 58168192, compound

HRID 1029160

Reaction equation

HRID 1029160 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[F:17][C:18]1([F:28])[O:22][C:21]2[CH:23]=[CH:24][CH:25]=[C:26]([NH2:27])[C:20]=2[O:19]1>>[F:28][C:18]1([F:17])[O:22][C:21]2[CH:23]=[CH:24][CH:25]=[C:26]([NH:27][C:2]3[CH:11]=[CH:10][N:9]=[C:8]4[C:3]=3[C:4]3[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=3[C:6](=[O:12])[NH:7]4)[C:20]=2[O:19]1

Participants

3

Reactant 2

HCID 27368912,2-Difluoro-1,3-dioxaindan-4-amineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168192HCID 58168192, compoundYield 77.2%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 2,2-difluoro-benzo[1,3]dioxol-4-ylamine (150 mg, 0.87 mmol) to provide 196 (122 mg, 77% yield) as a white solid. LC-MS (M+H=368, obsd.=368).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-9298ac35552149928b82e794018741d1
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Linked notes

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