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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1031277Generated: October 26, 2026

4-Toluenesulfonyl chloride → N-(4-methoxyphenyl)-4-methylbenzenesulfonamide

https://huagongshe.com/reaction/1031277

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
ReactantP-AnisidineHCID 7732—
ReagentSodium BicarbonateHCID 516892—
SolventAcetoneHCID 180—
SolventWaterHCID 962—
SolventPentaethylene glycolHCID 62551—
ProductN-(4-methoxyphenyl)-4-methylbenzenesulfonamideHCID 7085098%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/co400012m
Source dataset39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
ORD IDord-360f0e1373444a2b9571017ab7c7e186
Source note39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"