[6-(1H-Imidazol-1-yl)pyridin-3-yl]methanol → 6-(1H-iMidazol-1-yl)nicotinaldehyde
Reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][N:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1>C(Cl)(Cl)Cl.O=[Mn]=O>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH:12]=[O:13])=[CH:8][N:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
MnO2 (18.17 g) is added to a solution of the hydroxy methyl compound of Step 3. above (6.1 g) in CHCl3, and the resulting reaction mixture heated to reflux for 22 hours, allowed to cool, filtered, and the organic layer evaporated affording the desired product as a white solid used in the next step without further purification. M.P.=139.5°-140.5° C.
Workup
- temperatureheated
- temperatureto reflux for 22 hours
- temperatureto cool
- filtrationfiltered
- customthe organic layer evaporated
Sources & evidence
- ORD record
- ord-ec499654870d41699ff01b4c1ff1ecb1
- Source dataset
- uspto-grants-1990_09
- Patent number
- US04954494
Reaction notes
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