1,4-Dioxane hydrochloride → HCID 70041265, compound
Reaction equation
C(OC([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([NH:18][C:19](=[O:29])[C@H:20]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[NH2:21])=[O:17])[CH2:12][CH2:11]1)=O)(C)(C)C.[ClH:30].O1CCOCC1>>[ClH:30].[NH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]([NH:18][C:19](=[O:29])[C@H:20]([CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[NH2:21])=[O:17])=[CH:14][CH:15]=1Participants
3
Procedure
To the compound (I) (2.84 g), 4 N hydrogen chloride/1,4-dioxane solution (35 ml) under room temperature was added and the mixture was stirred at the same temperature for 2 hours. The mixture was concentrated under a reduced pressure, and the residue washed with ethyl ether, followed by filtration to give N-(4-aminomethylbenzoyl)-L-phenylalanine amide hydrochloride (2.32 g) as a white powder.
Workup
- concentrationThe mixture was concentrated under a reduced pressure
- washthe residue washed with ethyl ether
- filtrationfollowed by filtration