1,4-Dioxane hydrochloride → HCID 13689669, compound

Reaction equation

C(OC(NC[C@H]1CC[C@H]([C:16]([NH:18][C:19](=[O:29])[C@H:20]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[NH2:21])=O)CC1)=O)(C)(C)C.[ClH:30].O1CCOCC1>>[ClH:30].[CH3:16][NH:18][C:19](=[O:29])[C@H:20]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[NH2:21]

Participants

Reactant 2

HCID 204431481,4-Dioxane hydrochloride

HCID 178453621HCID 178453621, compound

Product 1

HCID 13689669HCID 13689669, compound

Procedure

To the compound (I) (2.00 g), 4N hydrogen chloride/1,4-dioxane solution (36 ml) was added, and the mixture was stirred under room temperature for one hour. The solvent was evaporated under a reduced pressure and toluene was added to the residue, followed by reevaporation to give L-phenylalanine methylamide hydrochloride quantitatively as a white powder.

Workup

customThe solvent was evaporated under a reduced pressure and toluene
additionwas added to the residue
customfollowed by reevaporation

Sources & evidence

ORD record: ord-25d45ab4575f448893b75d75b5648a25
Source dataset: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04954512

Reaction notes

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