Methyl iodide → N-benzyl-5,6-dihydroxy-N-methylisoindolinium iodide
Reaction equation
[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([OH:18])=[C:13]([OH:17])[CH:14]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][I:20]>CC(C)=O>[I-:20].[CH2:1]([N+:8]1([CH3:19])[CH2:9][C:10]2[C:15](=[CH:14][C:13]([OH:17])=[C:12]([OH:18])[CH:11]=2)[CH2:16]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
590 mg (2.44 mmol) of N-benzyl-5,6-dihydroxyisoindoline was dissolved in 10 ml of acetone, and 0.16 ml (2.5 mmol) of methyl iodide was added thereto at room temperature. The mixture was left to stand for 4 hours, and the precipitated crystals were collected by filtration and washed with 10 ml of acetone to obtain 733 mg of the above identified compound.