2-Methoxy-3-hydroxymethyl-5-ethyl-6-methylpyridine → 2-Methoxy-5-ethyl-6-methylnicotinaldehyde
Reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH2:9][OH:10])=[CH:7][C:6]([CH2:11][CH3:12])=[C:5]([CH3:13])[N:4]=1>C1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[N:4]=[C:5]([CH3:13])[C:6]([CH2:11][CH3:12])=[CH:7][C:8]=1[CH:9]=[O:10]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Activated manganese dioxide (2.0 g) was added to a solution of 2-methoxy-3-hydroxymethyl-5-ethyl-6-methylpyridine (1.18 g, 6.5 mmol) in dry benzene (20 mL) and refluxed 5-10 hours. The warm suspension was filtered through a pad of anhydrous Na2SO4 and evaporated to yield 1.05 g (90%) of a viscous oil which solidified.
Workup
- temperaturerefluxed 5-10 hours
- filtrationThe warm suspension was filtered through a pad of anhydrous Na2SO4
- customevaporated
Sources & evidence
- ORD record
- ord-97e0369315354bf597ed57db75aa3afc
- Source dataset
- uspto-grants-1994_05
- Patent number
- US05308854
Reaction notes
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