3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one → HCID 21836609, compound

HRID 1033399

Reaction equation

HRID 1033399 reaction equation
[NH2:1][CH:2]1[CH2:8][CH2:7][C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[NH:4][C:3]1=[O:13].[CH2:14]([O:21][C:22]([NH:24][C:25]([CH3:31])([CH3:30])[CH2:26][C:27](O)=[O:28])=[O:23])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:21][C:22]([NH:24][C:25]([CH3:31])([CH3:30])[CH2:26][C:27]([NH:1][CH:2]1[CH2:8][CH2:7][C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[NH:4][C:3]1=[O:13])=[O:28])=[O:23])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 44344333-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-oneHCID 145510073-(((Benzyloxy)carbonyl)amino)-3-methylbutanoic acid

Product 1

HCID 21836609HCID 21836609, compound

Procedure

Prepared from 3-amino-2,3,4,5-tetrahydro-1H[1]benzazepin-2-one (Example 1, Step A) and 3-benzyloxycarbonylamino-3-methylbutanoic acid (Example 1, Step E) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.38 (s,3H), 1.39 (s,3H), 1.82 (m,1H), 2.52 (s,2H), 2.5-3.0 (m,3H), 4.51 (m,1H), 5.07 (br s,2H), 5.58 (br s,1H), 6.68 (d,7 Hz, 1H), 6.96 (d,8 Hz, 1H), 7.1-7.4 (m,8H), 7.62 (br s, 1H). FAB-MS: calculated for C23H27N3O4 409; found 410 (M+H,100%).

Sources & evidence

ORD record
ord-d2a7dd0ed1594b2f8ba7ab5593f671ab
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Linked notes

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