Ammonium Chloride → HCID 15341843, compound

Reaction equation

[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8](OC)=[O:9])[CH2:3][CH2:2]1.[Cl-].[NH4+:18]>>[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8]([NH2:18])=[O:9])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 25517Ammonium Chloride

HCID 15341799HCID 15341799, compound

Product 1

HCID 15341843HCID 15341843, compound

Procedure

The compound of Example 15 is heated at 50° C. in a saturated ammonium chloride solution overnight. The reaction mixture is thoroughly extracted with ethyl acetate, and the solvent dried (Na2SO4) and evaporated in vacuo to afford the crude product. Chromatographic purification or silica gel using ethyl acetate/hexane (4:6) as eluant affords the product.

Workup

extractionThe reaction mixture is thoroughly extracted with ethyl acetate
dry with materialthe solvent dried (Na2SO4)
customevaporated in vacuo

Sources & evidence

ORD record: ord-c5a247d36daf45d3b8519925f5849b6b
Source dataset: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05310951

Reaction notes

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