Aluminium lithium hydride → (3-Fluoropyridin-4-yl)methanol

Reaction equation

[F:1][C:2]1[CH:12]=[N:11][CH:10]=[CH:9][C:3]=1[C:4](OCC)=[O:5].[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[F:1][C:2]1[CH:12]=[N:11][CH:10]=[CH:9][C:3]=1[CH2:4][OH:5]

Participants

Reactant 2

HCID 21226445Aluminium lithium hydride

HCID 46311382Ethyl 3-fluoroisonicotinate

Product 1

HCID 49760376(3-Fluoropyridin-4-yl)methanol

Procedure

The product of Example 129A and LiAlH4 were processed according to the method of Example 124B to provide the product. MS (ESI+) m/z 128 (M+H)+;

Workup

customto provide the product

Sources & evidence

ORD record: ord-9793ec7c79e043ac93817c6c461372ed
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546374B2

Reaction notes

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