2-Fluorobenzonitrile → 2-[(1-Methylpiperidin-3-yl)oxy]benzonitrile

HRID 1035110

Reaction equation

F[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:10][N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([OH:17])[CH2:12]1>>[CH3:10][N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([O:17][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH2:12]1

Participants

Reactant 2

HCID 678552-Fluorobenzonitrile

HCID 980163-Piperidinol, 1-methyl-

Product 1

HCID 685837202-[(1-Methylpiperidin-3-yl)oxy]benzonitrile

Procedure

2-Fluoro-benzonitrile was reacted with 1-methyl-piperidin-3-ol according to the method of Example 85A to provide the title compound. MS (DCI/NH3) m/z 217 (M+1)+.

Sources & evidence

ORD record: ord-ff7548581d614059b75f726fbfba52c5
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546374B2

Linked notes

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