2,5-Dimethoxybenzaldehyde → 1-(2,5-Dimethoxyphenyl)-3-phenyl-2-propyn-1-ol

HRID 1037165

Reaction equation

HRID 1037165 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.[CH3:20][O:21]C1C=CC(OC)=CC=1C=O>>[CH3:19][O:18][C:5]1[CH:4]=[CH:3][C:2]([O:21][CH3:20])=[CH:7][C:6]=1[CH:8]([OH:17])[C:9]#[C:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 667262,5-DimethoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 670676821-(2,5-Dimethoxyphenyl)-3-phenyl-2-propyn-1-olYield 93%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2,5-dimethoxybenzaldehyde (1.00 g, 6.02 mmol) was reacted to give the title compound (1.50 g, 93%). 1H NMR (400 MHz, DMSO-d6): δ 7.42-7.34 (m, 5H), 7.18-7.15 (d, 1H), 6.97-6.94 (d, 1H), 6.87-6.83 (m, 1H), 6.03-6.01 (d, 1H), 5.77-5.74 (d, 1H), 3.78 (s, 3H), 3.72 (s, 3H).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-7b69507aa3434071a330db35871aaa86
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Linked notes

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