2,3-Dimethoxyisonicotinaldehyde → HCID 67067768, compound

Reaction equation

[CH3:1][O:2][C:3]1[C:8]([CH:9]([OH:18])[C:10]#[C:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:7][CH:6]=C(OC)N=1.[CH3:21][O:22][C:23]1C(OC)=C(C=O)C=C[N:24]=1>>[CH3:21][O:22][C:23]1[C:3]([O:2][CH3:1])=[C:8]([CH:9]([OH:18])[C:10]#[C:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:7]=[CH:6][N:24]=1

Participants

Reactant 2

HCID 552629602,3-Dimethoxyisonicotinaldehyde

HCID 670678161-(2,6-Dimethoxy-pyridin-3-yl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 67067768HCID 67067768, compoundYield 86%

Procedure

Following the procedure used to prepare 1-(2,6-dimethoxy-pyridin-3-yl)-3-phenyl-prop-2-yn-1-ol, 2,3-dimethoxy-pyridine-4-carbaldehyde was reacted to give the title compound (1.08 g, 86%) as a white solid. LCMS (Method A): RT=4.11 min, [M+H]+=270.

Workup

customwas reacted

Sources & evidence

ORD record: ord-b3b4761e53a84762ac764af65cbacb3b
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546376B2

Reaction notes

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