N,N-dimethyl-m-phenylenediamine → HCID 66670065, compound

Reaction equation

Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH3:9])[CH:3]=1.[CH3:10][N:11]([CH3:19])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([NH2:18])[CH:13]=1>>[CH3:10][N:11]([CH3:19])[C:12]1[CH:13]=[C:14]([NH:18][C:2]2[CH:3]=[C:4]([NH:8][CH3:9])[N:5]=[CH:6][N:7]=2)[CH:15]=[CH:16][CH:17]=1

Participants

Reactant 2

HCID 76084N,N-dimethyl-m-phenylenediamine

HCID 3094796-chloro-N-methylpyrimidin-4-amine

Product 1

HCID 66670065HCID 66670065, compound

Procedure

The title compound is prepared analogously as described in Example 105A from (6-chloro-pyrimidin-4-yl)-methylamine and N,N-dimethyl-m-phenylenediamine. The crude product obtained after evaporation of the ethyl acetate layer is purified by flash chromatography (CH2Cl2/CH3OH).

Sources & evidence

ORD record: ord-22968072f82548bab1670855f6e41894
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08552002B2

Reaction notes

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