Acetic Anhydride → HCID 58938508, compound

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1.[C:17](OC(=O)C)(=O)[CH3:18]>>[CH3:17][C:18]1[N:10]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:8](=[O:9])[C:7]2[C:2]([N:1]=1)=[N:3][CH:4]=[N:5][CH:6]=2

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 58938487HCID 58938487, compound

Product 1

HCID 58938508HCID 58938508, compound

Conditions

Temperature: 120 °C

Procedure

Compound 23 (70.0 mg, 0.32 mmol) was mixed with 6 mL of acetic anhydride and the reaction mixture was stirred at 120° C. for 2 h while monitored by MS. The reaction mixture was then concentrated in vacuo to yield 75 mg of crude compound 24 which was used for the next step without further purification.

Workup

concentrationThe reaction mixture was then concentrated in vacuo

Sources & evidence

ORD record: ord-4f9edf472b2749fd9f2e4ed09783173b
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08552009B2

Reaction notes

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