5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

HRID 1039062

Reaction equation

HRID 1039062 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=[N:13][CH:12]=[N:11]1

Participants

4

Reactant 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

Product 1

HCID 167723276-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (100 mg, 0.523 mmol) from step 1 of this example was added Pd/C (111 mg, 0.105 mmol) and methanol (5.2 mL). Set the reaction on Parr Shaker at 50 psi (345 kPa) for overnight. The solution was filtered through CELITE and rinsed with methanol to give the title compound as a white solid.

Workup

  1. customthe reaction on Parr Shaker at 50 psi (345 kPa) for overnight
  2. filtrationThe solution was filtered through CELITE
  3. washrinsed with methanol

Sources & evidence

ORD record
ord-fbe714709af342a7b7b3c79361752d35
Source dataset
uspto-grants-2013_10
Patent number
US08552022B2

Linked notes

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