HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Pyridine → 5-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine fumarate

HRID 1040
Notes
Print preview

Reaction equation

HRID 1040 reaction equation
N1C=CC=CC=1.[C:7]([OH:14])(=[O:13])/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11].[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[C:24]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]3)[CH:25]=[N:26][CH:27]=2)=[CH:18][CH:17]=1>CO>[C:7]([OH:14])(=[O:13])/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11].[F:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[C:24]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]3)[CH:25]=[N:26][CH:27]=2)=[CH:20][CH:21]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 1049PyridineHCID 444972Fumaric AcidHCID 196942955-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine

Product 1

HCID 196942945-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine fumarateYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The above described pyridine derivative was converted into invention compound of Formula I by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25° C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether resulted in the formation of 5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate (70%) as a colorless solid.

Workup

  1. customAfter 30 minutes the solvent was removed in vacuo

Sources & evidence

ORD record
ord-78d0ff9eaef04c19a3803165f28b1df6
Source dataset
uspto-grants-1998_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05723477

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes