HCID 178521699, compound → HCID 178507185, compound
Reaction equation
C(OC(=O)[NH:10][C:11]1([C:14]2[NH:18][CH:17]=[N:16][N:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:16]1[N:15]=[C:14]([C:11]2([NH2:10])[CH2:13][CH2:12]2)[NH:18][CH:17]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of [1-(4H-[1,2,4]triazol-3-yl)-cyclopropyl]-carbamic acid benzyl ester (60 mg, 0.23 mmol) in MeOH (5 mL) was added 10% Pd/C (60 mg). The reaction mixture was stirred under H2 atmosphere (balloon) for 1.5 h. The reaction mixture was filtered through diatomaceous earth. The solvent was concentrated in vacuo and dried under high vacuum to afford 28 mg of the title compound, m/z 125.5 [M+1]+.
Workup
- filtrationThe reaction mixture was filtered through diatomaceous earth
- concentrationThe solvent was concentrated in vacuo
- customdried under high vacuum
Sources & evidence
- ORD record
- ord-b1cbcd54f9224bd88a8376b29afa1e1f
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08552205B2
Reaction notes
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