HCID 178521700, compound → HCID 178507186, compound
Reaction equation
C(OC(=O)[NH:10][C:11]1([C:14]2[NH:18][N:17]=[N:16][N:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[NH:15]1[C:14]([C:11]2([NH2:10])[CH2:13][CH2:12]2)=[N:18][N:17]=[N:16]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
[1-(1H-tetrazol-5-yl)-cyclopropyl]-carbamic acid benzyl ester was dissolved in MeOH (5 ml). The solution was passed through a H-Cube hydrogenator at 0 bar, 30° C. and 1 ml/min with 10% Pd/C as a catalyst. The elute was concentrated to afford 48 mg of 1-(1H-tetrazol-5-yl)-cyclopropylamine as a solid product, m/z 126.5 [M+1]+.
Workup
- concentrationThe elute was concentrated
Sources & evidence
- ORD record
- ord-1a589d74c5f941b19ed54273a8c12adf
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08552205B2
Reaction notes
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