HCID 89685058, compound → [3-(2-Methyl-1,3-dioxolan-2-yl)phenyl]methanamine
Reaction equation
[N:1]([CH2:4][C:5]1[CH:6]=[C:7]([C:11]2([CH3:16])[O:15][CH2:14][CH2:13][O:12]2)[CH:8]=[CH:9][CH:10]=1)=[N+]=[N-]>CO.[Pd]>[CH3:16][C:11]1([C:7]2[CH:6]=[C:5]([CH2:4][NH2:1])[CH:10]=[CH:9][CH:8]=2)[O:12][CH2:13][CH2:14][O:15]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of the crude azide (194 mg, 0.88 mmol) in MeOH (5 mL) was hydrogenated in the presence of Pd/C (10%) at rt until completion of the reaction. The reaction mixture was filtered and concentrated under reduced pressure to give the title compound as a pale yellow solid. LC-MS-conditions 02: tR=0.59 min; [M+H]+=194.64.
Workup
- filtrationThe reaction mixture was filtered
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-06cfe7fd07744a6c929b7b02d6f706e6
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08563714B2
Reaction notes
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