Phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate → Phenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylate

Reaction equation

[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[CH2:27]1>>[Br:1][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[CH2:27]1

Participants

Reactant 2

HCID 58306139Phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate

HCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 58306246Phenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylate

Procedure

Prepared similarly to Intermediate 30 from phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate.

Sources & evidence

ORD record: ord-8b070a4ac19a4a77b9fdbcf1f890bbd1
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08563717B2

Reaction notes

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