5-(1-Benzyloxycarbonyl-4-piperidyl)pentanol → Phenylmethyl 4-(5-bromopentyl)-1-piperidinecarboxylate

Reaction equation

[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH:27]1[CH2:32][CH2:31][N:30]([C:33]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:34])[CH2:29][CH2:28]1>>[Br:1][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH:27]1[CH2:32][CH2:31][N:30]([C:33]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:34])[CH2:29][CH2:28]1

Participants

Reactant 2

HCID 140469305-(1-Benzyloxycarbonyl-4-piperidyl)pentanol

HCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 58306239Phenylmethyl 4-(5-bromopentyl)-1-piperidinecarboxylate

Procedure

Prepared similarly to Intermediate 30 from phenylmethyl 4-(5-hydroxypentyl)-1-piperidinecarboxylate.

Sources & evidence

ORD record: ord-d6e91c7fd25645da8339c76313c76a0b
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08563717B2

Reaction notes

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