Phenylmethyl 4-(6-hydroxyhexyl)-1-piperidinecarboxylate → Phenylmethyl 4-(6-bromohexyl)-1-piperidinecarboxylate

Reaction equation

[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH:28]1[CH2:33][CH2:32][N:31]([C:34]([O:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[O:35])[CH2:30][CH2:29]1>>[Br:1][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH:28]1[CH2:33][CH2:32][N:31]([C:34]([O:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[O:35])[CH2:30][CH2:29]1

Participants

Reactant 2

HCID 58306109Phenylmethyl 4-(6-hydroxyhexyl)-1-piperidinecarboxylate

HCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 58306218Phenylmethyl 4-(6-bromohexyl)-1-piperidinecarboxylate

Procedure

Prepared similarly to Intermediate 30 from phenylmethyl 4-(6-hydroxyhexyl)-1-piperidinecarboxylate.

Sources & evidence

ORD record: ord-c5793d9783e0433a81ce8d727f4be8ee
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08563717B2

Reaction notes

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