1-Bromo-3-methylbutane → 6-Amino-2-(butyloxy)-9-{3-[1-(3-methylbutyl)-4-piperidinyl]propyl}-7,9-dihydro-8H-purin-8-one
Reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].Br[CH2:28][CH2:29][CH:30]([CH3:32])[CH3:31]>>[NH2:26][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:24])[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:28][CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:20][CH2:19]1Participants
3
Procedure
Prepared similarly to Example 14 from 2-(butyloxy)-8-(methyloxy)-9-[3-(4-piperidinyl)propyl]-9H-purin-6-amine and 1-bromo-3-methylbutane.
Sources & evidence
- ORD record
- ord-28cb614f811a41f1a77c85a4689aa201
- Source dataset
- uspto-grants-2013_10