Methyl 4-(bromomethyl)-3-methoxybenzoate → methyl 3-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate

HRID 1046277

Reaction equation

HRID 1046277 reaction equation
[C@H:1]12[CH2:7][C@H:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:8](OC(C)(C)C)=O.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:24]=[CH:25][C:26]=1CBr)[C:20]([O:22][CH3:23])=[O:21]>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:24]=[CH:25][C:26]=1[CH2:8][N:2]1[CH2:3][C@@H:4]2[CH2:7][C@H:1]1[CH2:6][NH:5]2)[C:20]([O:22][CH3:23])=[O:21]

Participants

3

Reactant 2

HCID 2759828Methyl 4-(bromomethyl)-3-methoxybenzoateHCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Product 1

HCID 68487145methyl 3-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate

Procedure

Following the above procedure, 1,1-dimethylethyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate and methyl 3-methoxy-4-(bromomethyl)benzoate are reacted together to give methyl 3-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate.

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-b09e844e9f124192868c71ea2be5da06
Source dataset
uspto-grants-2013_10
Patent number
US08569303B2

Linked notes

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