4-bromo-2,3-dihydro-1H-indol-2-one → 2-(4-bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-piperidin-1-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one

HRID 104774

Reaction equation

HRID 104774 reaction equation
[Br:23][c:24]1[c:25]2[c:29]([cH:30][cH:31][cH:32]1)[NH:28][C:27](=[O:33])[CH2:26]2.[CH3:1][c:2]1[c:3]([CH:21]=[O:22])[nH:4][c:5]2[c:6]1[C:7](=[O:20])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1)[CH2:9][CH2:10][CH2:11]2>>[CH3:1][c:2]1[c:3]([CH:21]=[C:26]2[c:25]3[c:24]([Br:23])[cH:32][cH:31][cH:30][c:29]3[NH:28][C:27]2=[O:33])[nH:4][c:5]2[c:6]1[C:7](=[O:20])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1)[CH2:9][CH2:10][CH2:11]2

Participants

3

Reactant 2

HCID 27631904-bromo-2,3-dihydro-1H-indol-2-oneHCID 592500973-Methyl-4-oxo-5-(2-piperidin-1-yl-ethyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-c]azepine-2-carbaldehyde

Product 1

HCID 685225712-(4-bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-piperidin-1-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one

Sources & evidence

ORD record
ord-3b7497439b364bf7934aa1dbd8f93219
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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