Phosphorus pentachloride → 1-Chloro-3-isocyanato-2-methylbenzene

HRID 1048616

Reaction equation

HRID 1048616 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][C:9](OC)=[O:10])[C:3]=1[CH3:13].P(Cl)(Cl)(Cl)(Cl)Cl>ClC1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]=[C:9]=[O:10])[C:3]=1[CH3:13]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 5045840HCID 5045840, compound

Product 1

HCID 27357701-Chloro-3-isocyanato-2-methylbenzene

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of the above-mentioned 1-chloro-2-methyl-3-methoxycarbonylaminobenzene 5.80 g, phosphorus pentachloride 7.53 g and chlorobenzene 50 mL was stirred with heating under reflux for one hour. The reaction mixtures were concentrated under reduced pressure to give 1-chloro-3-isocyanato-2-methylbenzene.

Workup

  1. temperaturewith heating
  2. temperatureunder reflux for one hour
  3. customThe reaction mixtures
  4. concentrationwere concentrated under reduced pressure

Sources & evidence

ORD record
ord-c07e86bf39de478ca7a81d6dc5d44939
Source dataset
uspto-grants-2016_07
Patent number
US09380782B2

Linked notes

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