Hydrazine → HCID 178509224, compound

HRID 1048745

Reaction equation

HRID 1048745 reaction equation
[NH2:1][NH2:2].[Br:3][C:4]1[CH:5]=[N:6][C:7](OC)=[C:8]([CH:11]=1)[C:9]#[N:10]>>[Br:3][C:4]1[CH:11]=[C:8]2[C:9]([NH2:10])=[N:2][NH:1][C:7]2=[N:6][CH:5]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 263699225-Bromo-2-methoxynicotinonitrile

Product 1

HCID 178509224HCID 178509224, compoundYield 72%

Procedure

35 ml (23.47 mmol) of hydrazine is added at room temperature to 5 g (23.47 mmol) of 5-bromo-2-methoxynicotinonitrile. The reaction medium is carried at 100° C. for 3 hours. After returning to room temperature, the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 3.6 g (72%) of 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-amine in the form of a yellow solid.

Workup

  1. customAfter returning to room temperature
  2. customthe precipitate obtained
  3. filtrationis filtered
  4. washrinsed with water
  5. customdried at 50° C.

Sources & evidence

ORD record
ord-8e26e5684f124936b17be9a8f0883a2a
Source dataset
uspto-grants-2016_07
Patent number
US09381195B2

Linked notes

Loading…