4-(3-Chloro 4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one → 4-(3-chloro-4-fluoro-phenylamino)-5-[5-(2-diethylamino-ethyl)-4-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-ylmethylene]-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one

HRID 104943

Reaction equation

HRID 104943 reaction equation
[CH2:1]([CH3:2])[N:3]([CH2:4][CH2:5][N:6]1[C:7](=[O:21])[c:8]2[c:9]([nH:12][c:13]([CH:19]=[O:20])[c:14]2[C:15]([F:16])([F:17])[F:18])[CH2:10][CH2:11]1)[CH2:22][CH3:23].[Cl:24][c:25]1[cH:26][c:27]([NH:32][c:33]2[c:34]3[c:35]([n:36][cH:37][n:38]2)[NH:39][C:40](=[O:42])[CH2:41]3)[cH:28][cH:29][c:30]1[F:31]>>[CH2:1]([CH3:2])[N:3]([CH2:4][CH2:5][N:6]1[C:7](=[O:21])[c:8]2[c:9]([nH:12][c:13]([CH:19]=[C:41]3[c:34]4[c:33]([NH:32][c:27]5[cH:26][c:25]([Cl:24])[c:30]([F:31])[cH:29][cH:28]5)[n:38][cH:37][n:36][c:35]4[NH:39][C:40]3=[O:42])[c:14]2[C:15]([F:16])([F:17])[F:18])[CH2:10][CH2:11]1)[CH2:22][CH3:23]

Participants

3

Reactant 2

HCID 98787694-(3-Chloro 4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-oneHCID 866376915-(2-diethylamino-ethyl)-3-trifluoromethyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Product 1

HCID 666083484-(3-chloro-4-fluoro-phenylamino)-5-[5-(2-diethylamino-ethyl)-4-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-ylmethylene]-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one

Sources & evidence

ORD record
ord-8a998748ac6745b3b89a80b60038c3e8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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