Nitric Oxide → Citrulline

Reaction equation

O[NH:2][C:3](=N)[NH:4][CH2:5][CH2:6][CH2:7][C@@H:8]([C:10]([OH:12])=[O:11])[NH2:9].N[C@H](C(O)=[O:24])CCCNC(=N)N.CC(O)=O.C(CN=C(NO)N)C[C@H](N)C(O)=O.[N]=O>>[NH2:9][C@H:8]([C:10]([OH:12])=[O:11])[CH2:7][CH2:6][CH2:5][NH:4][C:3]([NH2:2])=[O:24]

Participants

Reactant 4

HCID 145068Nitric Oxide

HCID 11957565NG-Hydroxy-L-arginine, Monoacetate Salt

HCID 178418600HCID 178418600, compound

HCID 178513439HCID 178513439, compound

Product 1

HCID 9750Citrulline

Procedure

Nω-hydroxy-L-arginine is the physiologically occurring intermediate of the NO synthase catalysed oxidation L-arginine. NOHA is oxidised in a further step of NO synthase, nitrogen monoxide being released and L-citrulline being formed.

Sources & evidence

ORD record: ord-c82d6adaa7a14ea584b46bf89266a60d
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09387185B2

Reaction notes

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