Methyl 3-bromo-4-(cyclopropylmethoxy)benzoate → Methyl 3-cyano-4-(cyclopropylmethoxy)benzoate

Reaction equation

Br[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH:14]1[CH2:16][CH2:15]1)[C:5]([O:7][CH3:8])=[O:6].[C:17](C1C=C(C=C(OC(C)C)C=1)C(OC)=O)#[N:18]>>[C:17]([C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH:14]1[CH2:16][CH2:15]1)[C:5]([O:7][CH3:8])=[O:6])#[N:18]

Participants

Reactant 2

HCID 67194639Methyl 3-bromo-4-(cyclopropylmethoxy)benzoate

HCID 67195394Methyl 3-cyano-5-isopropoxybenzoate

Product 1

HCID 66877477Methyl 3-cyano-4-(cyclopropylmethoxy)benzoate

Procedure

Prepared from methyl 3-bromo-4-(cyclopropylmethoxy)benzoate according to the procedure for methyl 3-cyano-5-isopropoxybenzoate. LCMS-ESI (m/z) calculated for C13H13NO3: 231.3; no m/z observed, tR=3.97 min.

Sources & evidence

ORD record: ord-56784031341c4f2ba9474b6c912c4b1d
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09388147B2

Reaction notes

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