Bromine → 7-bromo-1H,2H,3H-pyrazolo(1,5-a)imidazole hydrobromide
Reaction equation
[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][CH:7]=2)[CH2:3][CH2:2]1.[Br:9]Br>C(O)(=O)C>[BrH:9].[Br:9][C:7]1[CH:6]=[N:5][N:4]2[CH2:3][CH2:2][NH:1][C:8]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A 100-mL round-bottom flask was charged with 2,3-dihydro-1H-imidazo[1,2-b]pyrazole (1.7 g, 15.6 mmol) and acetic acid (5 mL). A solution of bromine (7.39 g, 46.2 mmol) in acetic acid (47 mL) was then added slowly. The resulting solution stirred for 3 h at room temperature. The reaction mixture was filtered and the filtrate was concentrated under vacuum to afford 7-bromo-2,3-dihydro-1H-imidazo[1,2-b]pyrazole hydrobromide (3.0 g, 72%) as a yellow solid. MS (ESI, pos. ion) m/z 188, 190 [M+H]+.
Workup
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated under vacuum
Sources & evidence
- ORD record
- ord-45c7491b04704cf98039878dd07ed3f3
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09388161B2
Reaction notes
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