3-(Trifluoromethyl)aniline → 4-Pyridinecarboxamide, 2-bromo-N-[3-(trifluoromethyl)phenyl]-

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[F:11][C:12]([F:21])([F:20])[C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=1)[NH2:16]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH:16][C:15]1[CH:17]=[CH:18][CH:19]=[C:13]([C:12]([F:11])([F:20])[F:21])[CH:14]=1)=[O:7]

Participants

Reactant 2

HCID 73753-(Trifluoromethyl)aniline

HCID 2227012-Bromoisonicotinic acid

Product 1

HCID 866958424-Pyridinecarboxamide, 2-bromo-N-[3-(trifluoromethyl)phenyl]-

Procedure

In a manner similar to that described in Preparation 17, 2-bromoisonicotinic acid and 3-trifluoromethylaniline were converted to the title compound

Sources & evidence

ORD record: ord-03b6a03d81134fcaad717b3426f1bcba
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09388176B2

Reaction notes

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