Water → 3-Bromo-6-chloro-2-methoxypyridine
Reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH3:10][O-:11].[Na+].O>C(#N)C>[Br:1][C:2]1[C:3]([O:11][CH3:10])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.
Workup
- customthe organic was evaporated
- filtrationThe resulting suspension was filtered
- washthe pad was washed with water for several times
- customThe pad was dried
Sources & evidence
- ORD record
- ord-6f02dd56485b4c9cbf12cee0cded4e36
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09394285B2
Reaction notes
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