4-(2-Bromoethyl)morpholine hydrochloride → 5-Bromo-4-(cyclobutylmethoxy)-1-methyl-3-(2-morpholin-4-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one

HRID 1056964

Reaction equation

HRID 1056964 reaction equation
[Br:1][C:2]1[CH:12]=[CH:11][C:5]2[N:6]([CH3:10])[C:7](=[O:9])[NH:8][C:4]=2[C:3]=1[O:13][CH2:14][CH:15]1[CH2:18][CH2:17][CH2:16]1.Cl.Br[CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[Br:1][C:2]1[CH:12]=[CH:11][C:5]2[N:6]([CH3:10])[C:7](=[O:9])[N:8]([CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[C:4]=2[C:3]=1[O:13][CH2:14][CH:15]1[CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 129555404-(2-Bromoethyl)morpholine hydrochlorideHCID 1180939015-bromo-4-(cyclobutylmethoxy)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

Product 1

HCID 1180938675-Bromo-4-(cyclobutylmethoxy)-1-methyl-3-(2-morpholin-4-ylethyl)-1,3-dihydro-2H-benzimidazol-2-one

Procedure

This compound was synthesized according to the procedure of Example 44, Step 2, using 5-bromo-4-(cyclobutylmethoxy)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one and 4-(2-bromoethyl)morpholine hydrochloride as the starting materials. LCMS calculated for C19H27BrN3O3 (M+H)+: m/z=424.1, 426.1. found: 424.3, 426.3.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-26f65818ad3d469f9078b5e78d736fb4
Source dataset
uspto-grants-2016_07
Patent number
US09399640B2

Linked notes

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