Cyclohexanemethanol → 4-Bromo-3-(cyclohexylmethoxy)-N-methyl-2-nitroaniline

Reaction equation

[Br:1][C:2]1[CH:9]=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1F.[CH:14]1([CH2:20][OH:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:21][CH2:20][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

Reactant 2

HCID 7507Cyclohexanemethanol

HCID 1180938324-Bromo-3-fluoro-N-methyl-2-nitroaniline

Product 1

HCID 1180939244-Bromo-3-(cyclohexylmethoxy)-N-methyl-2-nitroaniline

Procedure

This compound was synthesized according to the procedure of Example 11, Step 1, using 4-bromo-3-fluoro-N-methyl-2-nitroaniline and cyclohexanemethanol as the starting materials. LCMS calculated for C14H20BrN2O3 (M+H)+: m/z=343.1, 345.1. found: 343.0, 345.1.

Workup

customThis compound was synthesized

Sources & evidence

ORD record: ord-f282bd17319a4a07a980abc584e2a5d6
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09399640B2

Reaction notes

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