3-Methoxycatechol → 4-Methoxy-spiro[1,3-benzodioxole-2,1'-cycloheptane]

HRID 1057943Notes

Reaction equation

HRID 1057943 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[C:5]([OH:6])[C:4]=1[OH:10].CO[C:13]1(OC)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH3:1][O:2][C:3]1[C:4]2[O:10][C:13]3([CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[O:6][C:5]=2[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 136223-MethoxycatecholHCID 128928771,1-Dimethoxycycloheptane

Product 1

HCID 227340964-Methoxy-spiro[1,3-benzodioxole-2,1'-cycloheptane]

Procedure

Substantially the same procedure as in Reference Example 63 was repeated using 3-methoxycatechol (18 g) and dimethoxycycloheptane (24.35 g) to give Compound IIbm-a (28.0 g, 93.5%) as a colorless solid.

Workup

  1. customto give Compound IIbm-a (28.0 g, 93.5%) as a colorless solid

Sources & evidence

ORD record
ord-fe8006f3cf9c460a8aff2b7bee78aebf
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

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