2-(2-Bromoethoxy)tetrahydro-2H-pyran → HCID 178418986, compound

HRID 10585

Reaction equation

HRID 10585 reaction equation
Br[CH2:2][CH2:3][O:4]C1CCCCO1.[ClH:11].[CH:12]1[C:21]2[C:16](=[C:17]([NH:22][C@H:23]3[CH2:28][CH2:27][C@H:26]([NH2:29])[CH2:25][CH2:24]3)[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1>>[ClH:11].[CH:12]1[C:21]2[C:16](=[C:17]([NH:22][C@H:23]3[CH2:24][CH2:25][C@H:26]([NH:29][CH2:2][CH2:3][OH:4])[CH2:27][CH2:28]3)[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 178418802HCID 178418802, compound

Product 1

HCID 178418986HCID 178418986, compound

Procedure

According to the method of Example 144, an alkylation reaction with 2-(2-bromoethoxy)tetrahydro-2H-pyran and a deprotection reaction were performed by using the compound of Example 24 to obtain the title compound.

Workup

  1. customa deprotection reaction

Sources & evidence

ORD record
ord-ff1c7dcd2ff349b5ac91cf5866601436
Source dataset
uspto-grants-2006_08
Patent number
US07094789B2

Linked notes

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