2-(2-Bromoethoxy)tetrahydro-2H-pyran → HCID 178419099, compound

HRID 10586

Reaction equation

HRID 10586 reaction equation
Br[CH2:2][CH2:3][O:4]C1CCCCO1.[ClH:11].[CH3:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][C:21]=2[NH:23][C@H:24]2[CH2:29][CH2:28][C@H:27]([NH2:30])[CH2:26][CH2:25]2)[CH:16]=[N:15][CH:14]=1>>[ClH:11].[CH3:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][C:21]=2[NH:23][C@H:24]2[CH2:29][CH2:28][C@H:27]([NH:30][CH2:2][CH2:3][OH:4])[CH2:26][CH2:25]2)[CH:16]=[N:15][CH:14]=1

Participants

3

Reactant 2

HCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 178418877HCID 178418877, compound

Product 1

HCID 178419099HCID 178419099, compound

Procedure

According to the method of Example 144, an alkylation reaction with 2-(2-bromoethoxy)tetrahydro-2H-pyran and a deprotection reaction were performed by using the compound of Example 121 to obtain the title compound.

Workup

  1. customa deprotection reaction

Sources & evidence

ORD record
ord-c1f2ade017504966a4c64c8770e8d573
Source dataset
uspto-grants-2006_08
Patent number
US07094789B2

Linked notes

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