2-Iodotoluene → 1-tert-Butoxycarbonyl-4-[2-(2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

HRID 105891

Reaction equation

HRID 105891 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[c:15]([SH:21])[cH:16][cH:17][c:18]([F:20])[cH:19]2)([OH:22])[CH2:12][CH2:13]1.[I:23][c:24]1[c:25]([CH3:30])[cH:26][cH:27][cH:28][cH:29]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[c:15]([S:21][c:24]3[c:25]([CH3:30])[cH:26][cH:27][cH:28][cH:29]3)[cH:16][cH:17][c:18]([F:20])[cH:19]2)([OH:22])[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 51282-IodotolueneHCID 686821134-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 686842701-tert-Butoxycarbonyl-4-[2-(2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

Sources & evidence

ORD record
ord-f7a3f08859ec4a3e9474bd42ca044427
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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