1,2-Dibromobenzene → 1-(3-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

HRID 1059142

Reaction equation

HRID 1059142 reaction equation
[C:1]([N:20]1[CH:24]=[C:23]([C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[N:22]=[CH:21]1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:30]1[CH:35]=[C:34](Br)[C:33]([Br:37])=[CH:32][CH:31]=1>>[Br:37][C:33]1[CH:34]=[C:35]([C:25]([C:23]2[N:22]=[CH:21][N:20]([C:1]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH:24]=2)([OH:29])[CH:26]([CH3:28])[CH3:27])[CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 114141,2-DibromobenzeneHCID 10150490isopropyl(1-trityl-1H-imidazol-4-yl)ketone

Product 1

HCID 186685221-(3-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanolYield 76.5%

Procedure

By the reaction in the same manner as in Example 1-(ii) using 1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanone (34.90 g) and O-dibromobenzene (50.7 g), the title compound (37.7 g) was obtained as a colorless solid.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-0b6183ee55c344d7991f677affe8a9c4
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Linked notes

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