Pyridinium chloride → 1-(2',4'-difluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([C:20]2[N:21]=[CH:22][N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:24]=2)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:10]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([C:20]2[N:21]=[CH:22][NH:23][CH:24]=2)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:10]=1Participants
3
Procedure
By the reaction in the same manner as in Example 4-(iii) using 1-(2′,4′-difluoro[1,1′-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (6.31 g) and pyridine hydrochloride (2.17 g), the title compound (2.93 g) was obtained as colorless needle crystals.
Workup
- customBy the reaction in the same manner as in Example