Putrescine → N-(4-Aminobutyl)isoquinoline-5-sulfonamide

Reaction equation

Cl.[CH:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([S:12](Cl)(=[O:14])=[O:13])[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH2:16]([NH2:21])[CH2:17][CH2:18][CH2:19][NH2:20]>>[CH:2]1[C:11]2[C:6](=[C:7]([S:12]([NH:20][CH2:19][CH2:18][CH2:17][CH2:16][NH2:21])(=[O:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 1045Putrescine

HCID 13116932Isoquinoline-5-sulfonyl chloride hydrochloride

Product 1

HCID 13231162N-(4-Aminobutyl)isoquinoline-5-sulfonamideYield 61.9%

Procedure

According to the method of Reference Example 2, a reaction was performed by using isoquinoline-5-sulfonyl chloride hydrochloride (18.8 g) and 1,4-butylenediamine (25 g) to obtain the title compound (12.3 g).

Sources & evidence

ORD record: ord-ff4b8c61b8b94d78ab0ae7c76692603a
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07094789B2

Reaction notes

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