Benzyl (bis(2-methoxyethyl)amino)acetate → (Bis(2-methoxyethyl)amino)acetic acid
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:10][C:11]([O:13]CC1C=CC=CC=1)=[O:12])[CH2:6][CH2:7][O:8][CH3:9]>CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:10][C:11]([OH:13])=[O:12])[CH2:6][CH2:7][O:8][CH3:9]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of Example 81A (19.4 g; 69 mmol) and 10% Pd/C (3.5 g) in methanol (150 mL) at room temperature was stirred under 4 atm of H2 for 17 hours, filtered through diatomaceous earth (Celite®), and concentrated to provide the desired product.
Workup
- filtrationfiltered through diatomaceous earth (Celite®)
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-b8c16ed14b5c49159d2334e7dc94ba7a
- Source dataset
- uspto-grants-2003_02
- Patent number
- US06521658B1
Reaction notes
Loading…