Water → HCID 22283025, compound
Reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12]C(=O)O)[S:11][C:7]=2[C:6]([CH:16]=[CH2:17])=[CH:5][CH:4]=1.O>C(O)CO>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:16]=[CH2:17])=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
(4-Methoxy-7-vinyl-benzothiazol-2-yl)-carbamic acid methyll ester was dissolved in ethylenglycol/2N KOH (2:1) and stirred at 100° C. for 3 hrs. Then water was added and the mixture was extracted with CH2Cl2, the organic phase was washed with brine and dried over MgSO4. After evaporation the residue was crystallized from CH2Cl2. White crystals (64%); F.p.: 155-159° C.
Workup
- extractionthe mixture was extracted with CH2Cl2
- washthe organic phase was washed with brine
- dry with materialdried over MgSO4
- customAfter evaporation the residue
- customwas crystallized from CH2Cl2
- custom155-159° C.
Sources & evidence
- ORD record
- ord-5d9d853d8ebb429aae92605a7c289c71
- Source dataset
- uspto-grants-2003_02
- Patent number
- US06521754B2
Reaction notes
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