Thionyl Chloride → 4-(Methanesulfonyl)benzoyl chloride

HRID 1061859Notes

Reaction equation

HRID 1061859 reaction equation
[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].S(Cl)([Cl:16])=O>>[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:16])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 77670p-(Methylsulphonyl)benzoic acid

Product 1

HCID 112760134-(Methanesulfonyl)benzoyl chloride

Procedure

A mixture of 11.2 g (0.056 mol) of p-methylsulfonyl-benzoic acid prepared in Example 4 and 30 ml of thionyl chloride were heated under reflux to give a clear solution. Removal of the excess of thionyl chloride under reduced pressure obtained white solid and without purification put into the next reaction.

Workup

  1. temperaturewere heated
  2. temperatureunder reflux
  3. customto give a clear solution
  4. customRemoval of the excess of thionyl chloride under reduced pressure
  5. customobtained white solid
  6. customwithout purification
  7. customput into the next reaction

Sources & evidence

ORD record
ord-dc2391ad1b0d413495c6bf541d6f4f16
Source dataset
uspto-grants-2005_11
Patent number
US06960611B2

Reaction notes

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