Acetic Acid → 4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Reaction equation
Cl[C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12.[C:12](O)(=[O:14])C>C[O-].[Na+]>[CH3:12][O:14][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Compound 3 (70.4 g, 0.416 mol) was refluxed in methanolic sodium methoxide solution (25 g sodium dissolved in 1 L methanol) for 2 h. The reaction mixture was cooled to room temperature and neutralized by addition of acetic acid (75 ml). The mixture was evaporated to dryness and the solid was triturated in 600 ml of water, filtered and dried to provide 67.5 g (99% yield) of 4-methoxy-6-aminopyrazolo[3,4-d]pyrimidine (4).
Workup
- customThe mixture was evaporated to dryness
- customthe solid was triturated in 600 ml of water
- filtrationfiltered
- customdried
Sources & evidence
- ORD record
- ord-3142ad87d75e4854845801b740436dbc
- Source dataset
- uspto-grants-2005_11
- Patent number
- US06962991B2
Reaction notes
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