5-Amino-2-methylindole → HCID 69735873, compound

Reaction equation

[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.[CH2:12]([NH:14][C:15]([C:17]1[S:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][C:23]=2Cl)[CH:18]=1)=[O:16])[CH3:13]>>[CH2:12]([NH:14][C:15]([C:17]1[S:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][C:23]=2[NH:11][C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2]([CH3:1])=[CH:10]3)[CH:18]=1)=[O:16])[CH3:13]

Participants

Reactant 2

HCID 27339925-Amino-2-methylindole

HCID 69736414HCID 69736414, compound

Product 1

HCID 69735873HCID 69735873, compound

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-Chloro-thieno[3,2-b]pyridine-2-carboxylic acid ethylamide by a procedure analogous to Example 1C. MS: 351 (MH+); HPLC Rf: 4.33 min; HPLC purity: 98%.

Sources & evidence

ORD record: ord-ae4289169e004b2282f5bea7c37a81c9
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06964961B2

Reaction notes

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