5-Amino-2-methylindole → 7-(2-Methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carboxylic acid amide
Reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]([NH2:24])=[O:23])[S:21][C:14]=12>>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][C:13]1[CH:18]=[CH:17][N:16]=[C:15]3[CH:19]=[C:20]([C:22]([NH2:24])=[O:23])[S:21][C:14]=13)=[CH:6][CH:5]=2Participants
3
Procedure
The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridine-2-carboxylic acid amide by a procedure analogous to Example 1C. MS: 323 (MH+); HPLC Rf: 3.65 min; HPLC purity: 98%.
Sources & evidence
- ORD record
- ord-630c7ea758f640b79e142df1c5936cb7
- Source dataset
- uspto-grants-2005_11